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Snake Venom Antiserum I.P. Liquid and Lyophilized 

Generic Name:

Snake Venom Antiserum I.P. Liquid and Lyophilized

Description:

Snake venom is a drug made up of antibodies used to treat snake bites caused by venomous snakes. It's a kind of antidote.

 

It is a biological product composed of venom-neutralizing antibodies, usually derived from host animals such as horses and sheep. Host animals are hyperimmunized against one or more snake venoms. This is a process that triggers an immune response that produces numerous neutralizing antibodies against various components of the venom (toxins). Antibodies are then collected from the host animal and further processed into snake venom.

Snake Venom Antiserum Liquid and Lyophilized for India, Pakistan, Sri Lanka, Bangladesh and Nepal.

Composition:

Each bottle contains:

 

In 10ml polyvalent enzyme refined, Equine Immunoglobulins

Anti-Snake venom-Biovex.jpeg
Anti-snake venom-Biovex.jpeg

Dosage: 

Initial dose depends upon an estimate of the amount of envenomation as mentioned below: 

1. Minimal Envenomation - local swelling develops, but no systemic symptoms. We recommend dosing 5 vials (50 ml). 

2. Moderate Envenomation - Swelling beyond the bite site, mild systemic symptoms, and/or hematologic and coagulation abnormalities are present. We recommend dosing 5-10 vials (50-100 ml).

3. Severe Envenomation - Rapidly progressive and widespread local effects, systemic symptoms, and signs of hemolysis or coagulopathy. We recommend dosing at least 10-20 vials (100-200 ml). For children and small adults (weighing less than 40 kg), we recommend increasing the snake venom antiserum dose by up to 50%.

Indication:

Snake Venom Antiserum is indicated only for the treatment of envenomation caused by bites of the snakes specified.

Method of Administration:

Administer neat intravenously at a rate not to exceed 1 mL per minute or dilute with 500 mL of intravenous fluid (either sodium chloride injection or 5-dextrose injection) over 1-2 hours. dose as quickly as possible.

Presentation:

A container of 10mL Sterilized water for injections is included.

 

Contraindications:

Appropriate steps should be taken to determine the presence of dangerous hypersensitivity before administering products made from equine serum.

1. Careful review of the patient's medical history, including reports of asthma, urticaria, or other allergic symptoms.

2. Allergic reactions after contact with horses or previous horse serum injections. Appropriate sensitivity testing (skin testing) is recommended for each patient prior to administration, regardless of medical history.

Possible side effect:

a)The immediate reaction (shock & anaphylaxis) usually occurs within 30 minutes. Symptoms and signs may develop before the needle is withdrawn and include urticaria, edema of the face, tongue and throat, cough, dyspnea, cyanosis, vomiting and collapse. 

b) Serum sickness usually occurs 5 to 24 days after administration. The incubation period may be less than 5 days in those who have received horse serum containing preparations in the past. The usual symptoms and signs are fever, urticaria, edema, nausea and vomiting. Occasionally neurological manifestations develop. Pain and muscle weakness are frequently present.

Shelf Life:

36 months from the date of manufacture.

Storage:

Store at +2°C to +8°C. Do not freeze. Protect from light.

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